Conference on Retroviruses and Opportunistic Infections 2016

CROI, the annual Conference on Retroviruses and Opportunistic Infections (CROI), brings together top scientists, clinicians, and policy makers from around the world to discuss the latest studies and developments in the ongoing battle against HIV/AIDS and related infectious diseases. This year’s meeting is being held in February at the Hynes Convention Center in Boston, Massachusetts. Webcasts, abstracts, electronic posters, and other electronic resources are available online.

 

 

Below is a list of talks and posters by researchers associated with the Harvard AIDS Initiative and the Botswana Harvard AIDS Institute Partnership, being presented at this year’s CROI.


Tuesday, February 23
, 2016

SESSION 0-3 Oral Abstracts
11:00am Room 304/306
Prevention and Treatment of Pediatric HIV Infections

Similar Mortality With Cotrimoxazole vs Placebo in HIV-Exposed Uninfected Children

Roger L. Shapiro; Michael Hughes; Kathleen Powis; Gbolahan Ajibola; Kara Bennett; Sikhulile Moyo; Joseph Makhema; Sheryl Zwerski; M. Essex; Shahin Lockman

SESSION TD-2 Themed Discussion
1:45am –2:45pm Room 312
Global Burden and Mortality of Cancer in HIV
Themed Discussion Leader William A. Blattner, Institute of Human Virology, Baltimore, MD, USA

Cancer Versus Tuberculosis Mortality Among HIV-Infected Individuals in Botswana

Scott Dryden-Peterson; Gita Suneja; Heluf Medhin; Memory Bvochora-Nsingo; Mukendi K. Kayembe; Neo Tapela; Shahin Lockman

SESSION P-E1 Poster Abstracts
2:45pm-4:00pm Hall A/B
Antibody Responses to HIV Infection: What Drives Them and How They Affect the Virus

Humoral Immune Pressure Selects for HIV-1 CXCR4- Using Variants

Nina Lin; Oscar Gonzalez; Carlos Becerril; Behzad Etemad; Hong Lu; Xueling Wu; Shahin Lockman; M. Essex; Daniel Kuritzkes; Manish Sagar

SESSION P-S4 Poster Abstracts
2:45pm-4:00pm Hall D
MTCT: Regimens, Rates, and Early Infant Diagnosis

Infant Cotrimoxazole Prophylaxis Associated With Commensal Bacterial Resistance

Kathleen Powis; Sajini Souda; Shahin Lockman; Gbolahan Ajibola; Kara Bennett; Florence Chilisa; Michael Hughes; Sikhulile Moyo; Joseph Makhema; Roger L. Shapiro

HIV-Exposed Children Account for More Than Half of 24-Month Mortality in Botswana

Rebecca Zash; Jean Leidner; Sajini Souda; Kelebogile Binda; Heather J. Ribaudo; Sikhulile Moyo; Kathleen Powis; Joseph Makhema; Shahin Lockman; Roger L. Shapiro

Maternal ART and Hospitalization or Death Among HIV-Exposed Uninfected Infants

Scott Dryden-Peterson; Tatiana Ramos; Roger L. Shapiro; Shahin Lockman

SESSION P-T1 Poster Abstracts
2:45pm-4:00pm Hall D
Pharmacokinetics: Efficacy and Safety of New ARVs in Children

Nevirapine (NVP) Concentrations in HIV-Infected Newborns Receiving Therapeutic Dosing

Edmund Capparelli; Kenneth Maswabi; Steven Rossi; Muchaneta Bhondai; Sikhulile Moyo; Patrick Jean-Philippe; Michael Hughes; Mathias Lichterfeld; Daniel Kuritzkes; Roger L. Shapiro

SESSION P-W1 Poster Abstracts
2:45pm-4:00pm Hall D
Populations at Risk for HIV

Young HIV+ Adults in Botswana Less Likely to Seek Treatment or Be Virally Suppressed

Vladimir Novitsky; Tendani Gaolathe; Mompati Mmalane; Sikhulile Moyo; Molly Pretorius Holme; Kathleen Powis; Kathleen Wirth; Eric Tchetgen Tchetgen; Shahin Lockman; M. Essex

Wednesday, February 24, 2016

SESSION O-10 Oral Abstracts
10:00am Ballroom A
Getting to 90-90-90

Botswana Is Close to Meeting UNAIDS 2020 Goals of 90-90-90 Coverage

Tendani Gaolathe; Kathleen Wirth; Molly Pretorius Holme; Joseph Makhema; Sikhulile Moyo; Eric Tchetgen Tchetgen; Refeletswe Lebelonyane; Lisa A. Mills; M. Essex; Shahin Lockman

SESSION TD-10 Themed Discussion
1:45am –2:45pm Room 311
New Drugs for Kids: What’s Taking so Long?
Themed Discussion Leader Martina Penazzato, World Health Organization, Geneva, Switzerland

Nevirapine (NVP) Concentrations in HIV-Infected Newborns Receiving Therapeutic Dosing

Edmund Capparelli; Kenneth Maswabi; Steven Rossi; Muchaneta Bhondai; Sikhulile Moyo; Patrick Jean-Philippe; Michael Hughes; Mathias Lichterfeld; Daniel Kuritzkes; Roger L. Shapiro

SESSION P-O1 Poster Abstracts

2:45pm-4:00pm Hall A/B
Global Burden and Mortality of Cancer in HIV

Cancer Versus Tuberculosis Mortality Among HIV-Infected Individuals in Botswana

Scott Dryden-Peterson; Gita Suneja; Heluf Medhin; Memory Bvochora-Nsingo; Mukendi K. Kayembe; Neo Tapela ; Shahin Lockman

SESSION P-O2 Poster Abstracts
2:45pm-4:00pm Hall A/B
Anal and Cervical Cancer: Treatment and Prevention

HPV Type Distribution in HIV-Infected Persons With Anal HSIL and Impact on Recurrence

Michael Gaisa; Keith M. Sigel; Stephen Goldstone; Matthew Silverstein; Iain MacLeod

SESSION P-S5 Poster Abstracts
2:45pm-4:00pm Hall D
Mind the Gaps: Optimizing the PMTCT Cascade

Optimizing PMTCT Outcomes in Rural North-Central Nigeria: A Cluster-Randomized Study

Muktar H. Aliyu; Meridith Blevins; Carolyn M. Audet; Marcia Kalish; Mary Lou Lindegren; Usman I. Gebi; Obinna Onwujekwe; Bryan E. Shepherd; C. William Wester; Sten H. Vermund

SESSION P-S7 Poster Abstracts
2:45pm-4:00pm Hall D
Birth Outcomes and Mortality in HIV- and ARV-Exposed Infants

Higher Mortality in HIV-Exposed/Uninfected vs HIV-Unexposed Infants, Botswana

Gbolahan Ajibola; Gloria Mayondi; Jean Leidner; Haruna Jibril; Joseph Makhema; Mompati Mmalane; Modiegi Diseko; Roger L. Shapiro; Betsy Kammerer; Shahin Lockman

SESSION P-X3 Poster Abstracts
2:45pm-4:00pm Hall D
HIV Testing and Prevention

Cross-Sectional HIV Incidence at Scale-up of ART in 24 Rural Communities in Botswana

Sikhulile Moyo; Coretah Boleo; Terence Mohammed; Lucy Mupfumi; Simani Gaseitsiwe; Rosemary Musonda; Erik van Widenfelt; Joseph Makhema; M. Essex; Vladimir Novitsky

Thursday, February 25, 2016

SESSION TD-14 Themed Discussion
1:45am –2:45pm Room 302
Mind the Gaps: Optimizing the PMTCT Cascade
Themed Discussion Leader Marcel Yotebieng, Ohio State University, Columbus, OH, US

Optimizing PMTCT Outcomes in Rural North-Central Nigeria: A Cluster-Randomized Study

Muktar H. Aliyu; Meridith Blevins; Carolyn M. Audet; Marcia Kalish; Mary Lou Lindegren; Usman I. Gebi; Obinna Onwujekwe; Bryan E. Shepherd; C. William Wester; Sten H. Vermund

SESSION P-G5 Poster Abstracts
2:45pm-4:00pm Hall A/B
Clinical Distinctions and Therapeutic Response

Statin or ACE/ARB Effects on Neurocognitive Function of HIV-Infected Adults

Kristine M. Erlandson; Douglas Kitch; C. William Wester; Robert Kalayjian; Edgar T. Overton; Jose R. Castillo-Mancilla; Susan L. Koletar; Constance A. Benson; Kevin R. Robertson; Judith Lok

SESSION P-S9 Poster Abstracts
2:45pm-4:00pm Hall D
Outcomes of HIV and ARV-Exposed Infants, Children, and Youth

Similar HIV Protection From ZDV vs NVP Prophylaxis in Formula-Fed Infants in Botswana

Kathleen Powis; Shahin Lockman; Gbolahan Ajibola; Kara Bennett; Jean Leidner; Michael Hughes; Sikhulile Moyo; Erik van Widenfelt; Joseph Makhema; Roger L. Shapiro

SESSION P-X7 Poster Abstracts
2:45pm-4:00pm Hall D
Access, ART Initiation, Retention, and Outcomes in the Global South

Imputing Clinical Records From Routine Laboratory Data: Date of ART Initiation

Mhairi Maskew; Jacob Bor; Cheryl J. Hendrickson; William B. MacLeod; Till Bärnighausen; Deenan Pillay; Ian M. Sanne; Sergio Carmona; Wendy Stevens; Matthew P. Fox

SESSION P-X8 Poster Abstracts
2:45pm-4:00pm Hall D
Viral Suppression

Measuring Viral Load Suppression in South Africa Using a Novel, National Database

William B. MacLeod; Jacob Bor; Nicole Fraser; Zara Shubber; Ian M. Sanne; Wendy Stevens; Tshepo Molapo; Mokgadi Phokojoe; Yogan Pillay; Sergio Carmona

Harvard President, Drew Faust, Visits Botswana

President Faust visiting BHP
(Gaborone, Botswana – November 25, 2009) Harvard University President Drew Faust visited the Botswana – Harvard AIDS Initiative for HIV Research and Education (BHP). BHP is a collaborative research and training initiative between the Government of the Republic of Botswana and the Harvard AIDS Initiative. Among those in attendance were Professor Max Essex and Professor Ric Marlink. This occasion was the first time a standing Harvard President had made an official visit to the continent.
Staff Photo Justin Ide/Harvard University News Office

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

President Faust at BHP
(Gaborone, Botswana – November 25, 2009) Harvard University President Drew Faust visited the Botswana – Harvard AIDS Initiative for HIV Research and Education (BHP). BHP is a collaborative research and training initiative between the Government of the Republic of Botswana and the Harvard AIDS Initative. Among those in attendance were Dr. Joe Makhema and Professor Ric Marlink.
Staff Photo Justin Ide/Harvard University News Office

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Drew Faust at Training Center at BHP. 2009
Dr. Joe Makhema, President Drew Faust, Dr. Tendani Gaolathe, Ms. Christine Bussmann and Prof Ric Marlink at Training Center at BHP. 2009

KITSO AIDS Training Program reaches 8000+ milestone

KITSO AIDS Training Program reaches its 8000th person trained
KITSO AIDS Training Program reaches its 8000th person trained – 2008

The KITSO AIDS Training Program in Botswana reached the milestone of having trained over 8000 nurses, doctors and pharmacists in the fundamentals of HIV/AIDS care for the expanding Masa Programme. KITSO is the Setswana word for “knowledge“. Recently a detailed summary of the results of the training program and its support to the national ART treatment program in Botswana was published in the Open AIDS Journal, 2008, 2, 10 – 16.

Since its inception in the year 2000 by Dr. Richard Marlink and colleagues at the Botswana-Harvard Partnership, the KITSO AIDS Training Program has worked under the coordination of the MOH to increase local staff capacity within the healthcare sector and ensure the sustainability of HIV/AIDS care and treatment.

When ARV therapy was first introduced in Botswana in 2002, few physicians and nurses in the country had experience in AIDS treatment. Through KITSO training and front-line experience in the ARV clinics, healthcare professionals in Botswana have gained the expertise and confidence to both provide ARV therapy and train other healthcare workers at their treatment sites. KITSO-trained staff now provide ARV therapy at 33 hospital sites and 137 satellite clinics throughout the country, and currently serve over 130,000 patients enrolled in the national ARV program.

Curriculum and Implementation

2010_curriculum
KITSO has developed a module-based training curriculum which is tailored to the Botswana National HIV/ AIDS Treatment Guidelines. The curriculum has been collaboratively developed and is regularly updated by national and international experts to ensure that healthcare professionals gain competency and confidence in the latest national standards of HIV/AIDS care and treatment.

Curriculum development and course implementation have been driven by the immediate need to train Botswana’s healthcare workers in HIV/AIDS care in formats that provide a comprehensive grounding in good clinical practice without requiring long periods of staff release for training.

As mandated by the MOH, KITSO training modules are the national standard of training for HIV/AIDS care and treatment in both public and private sectors. The KITSO-BHP team oversees the standardized training implementation, curriculum development, updating, course examination and certification.

AIDS Clinical Care Fundamentals
Since its first offering in July 2001, AIDS Clinical Care Fundamentals (ACCF) has served as a gateway course to prepare Botswana’s healthcare professionals to provide basic ARV therapy and other HIV/AIDS care. Training is carried out using either a facility-based or centralized format, depending upon the staffing needs of individual healthcare facilities. Between July 2001 and December 2009, 7078 healthcare workers completed this module. Following four days of lectures and case study discussions, the course concludes with a final examination. Participants who meet course requirements as determined by the MOH receive a certificate of successful completion.

2010_accf_cdrom

The ACCF module has been packaged onto a CD-Rom for distance learning.

Since 2006 KITSO AIDS Training Program has been implementing distance learning as an alternative training format utilizing an audio-enhanced CD ROM of AIDS Clinical Care Fundamentals. Distance learning participants receive a training package, including the CD Rom, course binder and support materials for their self studies. A one-day classroom training activity where clinical scenarios pertaining to the learning objectives of the course are discussed. A final assessment concludes the distance learning experience.

Topics covered in AIDS Clinical Care Fundamentals:
1. Introduction to the Botswana National ARV Program
2. HIV Epidemiology and Pathophysiology
3. Laboratory Diagnostics in HIV/AIDS Care
4. Principles of ARV Therapy in the Botswana National Programme
5. Pediatric-and Adolescent-Specific Issues in HIV/AIDS Care
6. Pediatric-and Adolescent-Specific Issues in HIV/AIDS Psychosocial Care
7. ARV Drug Side Effects and Toxicities
8. Drug-Drug Interactions in ARV Therapy
9. Treatment Failure and Its Management
10. Adherence in ARV Therapy
11. Adult and Pediatric Opportunistic Infections and Other Complications in HIV Disease
12. Mother-to-Child Transmission and Its Prevention
13. Post-Exposure Prophylaxis (PEP)
14. TB and HIV Co-Infection
15. Summary of the Major Changes in the 2008 Guidelines.

AIDS Clinical Care Fundamentals Refresher/Update
This two-day Refresher/Update training module was developed in response to a high demand for refresher training, as well as the need to update already trained healthcare staff on the most recent changes to the national treatment guidelines. Incorporating information from the new guidelines along with care and treatment fundamentals, the training covers HIV testing, ARV therapy eligibility, principles of ARV therapy, management of toxicities, management of treatment failure, PMTCT, and treatment of TB and other opportunistic infections.

The module was first implemented in January 2008. All efforts will be made to re-train healthcare workers as quickly as possible in order to maintain the high standard of HIV/AIDS care and treatment in Botswana.

Medication Adherence Counseling
This three-day course is designed to enhance the adherence counseling skills of healthcare workers. Offered as a centralized training for nurses, pharmacy staff, and social workers from ARV treatment centers, Medication Adherence Counseling focuses on strategies to overcome potential barriers to adherence.

A combination of lectures, case discussions, role-playing, and interactive activities are employed to reinforce good counseling techniques and strengthen the participants’ ability to devise and implement successful adherence interventions. Implemented in collaboration with the Botswana-Baylor Children’s Center of Excellence, the course also includes teaching and case discussions about pediatric and adolescent adherence, as well as disclosure of HIV status for children, adolescents, and their families.

Advanced HIV/AIDS Care and Treatment Training
This advanced training is designed for physicians and pharmacists providing ARV therapy in Botswana. Course participants must have previously completed AIDS Clinical Care Fundamentals and be actively involved in an ARV clinic.

2010_advhiv

Training participants involved in clinical case discussions with on-looking KITSO faculty

Advanced HIV/AIDS Care and Treatment combines lectures and interactive case discussions to provide advanced and comprehensive training in ARV therapy, emphasizing treatment principles and strategies practiced world-wide and applying them to the Botswana setting. This course familiarizes participants with the full complement of ARV drugs and provides strategies for the management of treatment failure, interpretation of drug resistance assays, designing of “salvage” regimens, and understanding short- and long-term ARV side effects and toxicities. Course content equips clinicians with the skills and knowledge necessary to manage complicated patients and provide guidance and support to their colleagues, thereby strengthening the growing HIV treatment expertise in Botswana’s healthcare sector.

Advanced HIV/AIDS Care and Treatment covers adult, adolescent, and pediatric HIV care. Special emphasis is placed on primary care for HIV-infected children and on disclosure issues, especially in regards to children and adolescents.

Each advanced course also provides updates on relevant research and clinical trials conducted internationally and in Botswana as well as summaries of recent international HIV/AIDS meetings.

Introduction to AIDS Clinical Care
In 2009 this satellite training module was upgraded from a one-day to a two-day training. The training provides nonmedical professionals with a basic understanding of identification and management of HIV/AIDS in Botswana.

Course content includes an introduction to HIV pathophysiology and immunology and information about testing, eligibility and referral for ARV therapy, identification of common ARV side effects, the importance of medication adherence, counseling and referral for PMTCT, and post-exposure prophylaxis. This course is suitable for general health educators, family welfare educators, and lay counselors and social workers. Since 2006, Introduction to AIDS Clinical Care has been implemented at ARV sites by the BHP–PEPFAR Master Trainer Program.

Sexual and Reproductive Health in HIV Infection
This new module provides training for health professionals providing counseling and care in sexual and reproductive health issues for persons living with HIV. The course will empower health care workers to identify and manage sexual and reproductive health issues pertaining to HIV infection, such as STIs, family planning including conception and contraception, sexual dysfunctions, menopause, pregnancy and PMTCT, and HIV prevention. Implementation of this module started 2010.

Reference Corners and Resource Materials
KITSO AIDS Training Program has established “reference corners” in the medical libraries of Botswana’s two referral hospitals, Princess Marina Hospital and Nyangabgwe Hospital. Resources in these reference corners include textbooks, medical reference guides, specialized journal subscriptions, and relevant handbooks and guidelines.

KITSO AIDS Training Program has also provided each district hospital in Botswana with a laptop computer and an LCD projector for in-service staff education.

Collaborations
KITSO AIDS Training Program owes its success both to ACHAP for its financial support and to the dedicated faculty members from the Botswana MOH and Ministry of Local Government, the ACHAP Clinical Preceptorship Program, Botswana-Baylor Children’s Clinical Center of Excellence, Botswana-Harvard Partnership, University of Pennsylvania, the PEPFAR Master Trainer Program, the Private Practitioner Association of Botswana, and the World Health Organization.